The current study's goal was to improve the solubility and dissolution rate of the anti-diabetic medication repaglinide using nanocrystallization techniques. The approach used to increase solubility was nanocrystallization, which involves reducing the particle size of the medication, enhancing its solubility and dissolving properties. Various polymers in varying ratios were employed, including HPMC K4M, PVP K90 and PEG 6000. The medicine and polymers were initially examined for interaction and it was discovered that they are compatible. The solubility research revealed that the optimized batch's solubility improved to 40.068 mg/ml in demineralized water and 160.182 mg/ml in phosphate buffer, whereas the pure drug's solubility was 4.174 mg/ml in demineralized water and 20.547 mg/ml in phosphate buffer. The optimized formulation had the highest percent drug release in 2 hours at 87.91%, compared to all other batches. The stability research demonstrated that the manufactured nanocrystal exhibits no minor changes and hence may be classified as stable. The produced nanocrystals demonstrate that this nanocrystallization technology can be effective in enhancing the solubility and dissolution rate of drugs with low solubility and bioavailability.
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